Tilman Breiderhoff

Dr. Tilman Breiderhoff serves as Group Leader of the Genome Engineering Unit at the German Center for Neurodegenerative Diseases (DZNE) in Munich, Germany, operating from the Center for Stroke and Dementia Research (CSD) in Großhadern. His unit specializes in generating advanced mouse models for dementia, frontotemporal lobar degeneration (FTLD), and amyotrophic lateral sclerosis (ALS).

His research focuses on genome engineering applications including CRISPR/Cas9-mediated genetic modifications, development of point mutations and conditional knock-out models, and molecular dissection of neurodegenerative disease mechanisms. The unit provides centralized expertise in targeting strategy design, model validation, and mutant analysis for preclinical therapeutic development.

Under Dr. Breiderhoff's direction, the Genome Engineering Unit continuously develops refined genome editing methods to improve targeting efficiency while reducing unintended mutations and animal usage. No information was available regarding student advising, grant funding, or scientific awards in the provided materials.