معرفی
Thushara Madanayake is an Associate Research Scientist in the Department of Therapeutic Radiology at Yale School of Medicine. His research focuses on molecular mechanisms in oncology, radiation biology, and nanomedicine applications. He explores therapeutic strategies targeting epidermal growth factor receptor (EGFR) signaling pathways and develops novel drug delivery systems using nanotechnology. His work integrates molecular biology, transcriptomics, and pharmacology to understand cancer progression and treatment efficacy.
Key research interests include RNA splicing aberrations in renal cell carcinoma, peroxisomal metabolism regulation via TMEM135, and HMGB1's role in oncogene activation. He investigates the biocompatibility and therapeutic potential of magnetic nanoparticles and porphyrin-based materials for cancer therapy. His studies also address the physiological roles of cytochrome P450 enzymes in bronchial epithelial cells.
Publications highlight interdisciplinary approaches combining nanoplatform engineering, genetic manipulation, and cellular imaging to advance targeted therapies. His work bridges basic science discoveries with translational applications in precision oncology and radiation medicine.
