معرفی
Dr. Thomas MacVicar serves as a Senior Lecturer at the CRUK Scotland Institute, University of Glasgow, with contact details including telephone 01413302066 and email Thomas.MacVicar@glasgow.ac.uk.
His research integrates urological oncology and mitochondrial molecular mechanisms, focusing on prostate, bladder, and kidney cancers. Key investigations include mitochondrial double-stranded RNA regulation during cell-cycle progression and NME6-mediated ribonucleotide synthesis for mitochondrial gene expression. This work bridges cancer biology with fundamental cellular metabolism, aiming to identify therapeutic targets through understanding mitochondrial dysfunction in tumor progression.
Recent publications demonstrate a cohesive focus on mitochondrial stress responses in cancer contexts. The 2024 study reveals cell-cycle-dependent control of mitochondrial RNA homeostasis, while the 2023 EMBO Journal paper establishes NME6's critical role in nucleotide metabolism for mitochondrial transcription. Collectively, these findings highlight metabolic vulnerabilities in cancer cells with implications for urological malignancies.
Though specific advising details and grant funding are unlisted in the source, his active publication record in high-impact journals suggests ongoing mentorship of graduate researchers and sustained competitive research support within the CRUK Scotland Institute framework.
As part of the CRUK Scotland Institute's multidisciplinary environment, Dr. MacVicar contributes to collaborative cancer research initiatives leveraging advanced molecular and cellular facilities, fostering translational science across the University of Glasgow's biomedical ecosystem.
