معرفی
Sushma Nagaraja Grellscheid is a Professor at the Computational Biology Unit (CBU) and affiliated with the Department of Informatics at the University of Bergen. She holds a dual appointment at the Department of Biosciences and serves as Head of Node for ELIXIR-Norway, leading national bioinformatics infrastructure initiatives. Her research integrates computational and experimental biology to study post-transcriptional gene regulation, with a focus on alternative splicing in aging, cancer, and retinal diseases like retinitis pigmentosa. She also investigates the biophysics of biomolecular condensates, particularly stress granules, using multidisciplinary approaches combining cell biology, physics, and computational modeling.
Her research group at the University of Bergen is known for developing novel methods in transcriptomics, including adaptive tissue deconvolution and ribosome profiling analysis. She has pioneered studies on how RNA-binding proteins regulate splicing in senescence and cancer progression, with recent work extending to the physical properties of condensates in cellular organization. As a leader in ELIXIR-Norway, she drives FAIR data practices and infrastructure for life science research in Norway.
Key contributions include uncovering molecular mechanisms linking splicing defects to neurodegenerative diseases and advancing synthetic biology approaches for coacervate-based biomaterials. Her work spans from mechanistic cellular studies to large-scale data integration, reflecting her dual expertise in computational and experimental biology.
- Advising: Supervised Katarzyna Chyzynska's doctoral thesis on translational regulation via ribosome profiling.
- Labs/Teams: Leads the Grellscheid Group, a collaborative team of biologists, computational scientists, and physicists.
- Grants/Awards: No specific awards mentioned, but her leadership role in ELIXIR-Norway underscores her national and international recognition.
