Susan Harkness Regli

Susan Harkness Regli, PhD, serves as Human Factors Scientist for the University of Pennsylvania Health System and is a founder of Penn Medicine’s Center for Applied Health Informatics, driving innovation at the intersection of human factors engineering and healthcare delivery.

Her research program focuses on critical healthcare challenges through:

• Human-Computer Interaction in clinical environments
• Patient safety systems design
• Clinical decision support optimization
• Healthcare applications of AI and machine learning
• Natural language processing for medical data
• Human factors in sepsis management and insulin safety

Analysis of her 2009-2023 publications reveals consistent emphasis on real-world healthcare human factors, with recent work addressing sepsis diagnosis workflows, insulin pen safety protocols, and augmented reality applications. Her scholarship demonstrates methodological diversity spanning qualitative clinician interviews, heuristic evaluations, and quality improvement projects focused on error prevention in high-stakes medical environments.

As co-founder of Penn Medicine’s Center for Applied Health Informatics, Dr. Regli leads strategic initiatives that bridge human factors science with clinical informatics to develop practical solutions for healthcare delivery systems, fostering collaborations between engineers, clinicians, and data scientists to enhance patient safety through technology design.