Stéphane Bonacorsi

Stéphane Bonacorsi is a Professor (PU-PH) at Université Paris Cité, conducting research through IAME (Institut de Recherche en Infectiologie de Paris) where he leads the EVREST team. His work bridges academic microbiology and pediatric clinical practice, focusing on severe bacterial infections in children.

• Affiliation: Université Paris Cité, IAME Research Institute
• Research Unit: EVREST team specializing in pediatric bacterial pathogenesis

His research centers on pediatric E. coli infections, with emphasis on meningitis, urinary tract infections, and hemolytic uremic syndrome. He investigates molecular epidemiology, virulence mechanisms, and antibiotic resistance evolution using genomic approaches. Key areas include:

• Hybrid pathotypes (e.g., STEC/ESBL-producing E. coli O80)
• Neonatal meningitis pathogenesis
• European surveillance of emerging resistant strains
• Therapeutic target identification via sequencing

Analysis of his 15 most recent publications (2014-2025) reveals dominant focus on E. coli molecular epidemiology in children, with 73% addressing antibiotic resistance mechanisms and 40% involving genomic characterization of hybrid virulence/resistance traits. Over half specifically study meningitis or UTIs in pediatric populations.

His scientific contributions include:

• Defining characteristics of emerging E. coli clones (ST301, O80:H2)
• Mechanistic studies of virulence factors (e.g., ssbL gene in meningitis)
• Population-based sepsis surveillance in neonates
• Therapeutic evaluations for resistant infections

Bonacorsi's work demonstrates strong clinical translation, with studies directly informing pediatric infection management. His EVREST team maintains active surveillance of pathogen evolution in French hospitals, generating genomic resources for tracking resistance spread and identifying novel treatment approaches for life-threatening childhood infections.