معرفی
Dr. Steven Kleinstein is the Anthony N. Brady Professor of Pathology at the Yale School of Medicine, with secondary appointments in Immunobiology and Biomedical Informatics. He is Co-Director of Graduate Studies in Computational Biology and Biomedical Informatics, and leads the Kleinstein Lab. His research focuses on computational immunology, integrating big data analysis with immunology to study immune responses, including B cell receptor (BCR) repertoire profiling via AIRR-seq and multi-omic studies of infection/vaccination responses. Dr. Kleinstein holds a BAS in Computer Science from the University of Pennsylvania (1994) and a PhD in Computer Science from Princeton (2002). He is a member of the Computational Biology and Bioinformatics Program and the Human and Translational Immunology Program.
- Education:
- B.A.S. in Computer Science, University of Pennsylvania, 1994
- Ph.D. in Computer Science, Princeton University, 2002
Research Interests: His lab develops computational tools (e.g., Immcantation framework) for analyzing BCR repertoires and immune responses to pathogens like SARS-CoV-2, HIV, and influenza. Key projects include understanding germinal center B cell maturation, antibody specificity prediction via language models, and immune correlates of disease severity in hospitalized patients. Collaborations span clinical and basic science groups to apply these methods to autoimmune diseases, allergies, and cancer.
Grants & Collaborations: Active in NIH/NIAID initiatives (e.g., HIPC, PRIME) and industry partnerships. Lab members collaborate with institutions globally on projects like the IMPACC study and malaria vaccine research.
Labs/Teams: The Kleinstein Lab at Yale is part of the Center for Biomedical Data Science and the Yale Cancer Center, emphasizing computational and experimental immunology integration.
