Stephanie Kjærulff Holm

Stephanie Kjærulff Holm serves as a Research Fellow in the Clemmensen Group at the Faculty of Health and Medical Sciences, University of Copenhagen. Her primary research focus centers on metabolic regulation, particularly investigating LEAP2 (Liver-Expressed Antimicrobial Peptide 2) and its interactions with key metabolic hormones.

Dr. Holm's research program examines how metabolic states and interventions influence hormone signaling pathways related to appetite and weight control. Her work spans multiple experimental approaches, including mouse models of metabolism, human clinical studies, and molecular analyses of hormone production. She has made significant contributions to understanding how insulin, glucagon, ketone bodies, and dietary components regulate LEAP2 function and how these mechanisms relate to metabolic disorders.

Analysis of her publication record from 2022-2025 reveals a cohesive research trajectory focused on the intersection of nutrition, pharmacology, and endocrine signaling in metabolic regulation. Her work frequently examines LEAP2 in relation to established metabolic pathways including GDF15-GFRAL signaling and incretin hormone systems, with implications for obesity and diabetes therapeutics.

Dr. Holm maintains an active collaborative network within the metabolic research community, working with prominent researchers in the field including Clemmensen, Holst, and Knop. Her research has been published in high-impact journals such as Cell Reports Medicine, Diabetes, and Molecular Metabolism, demonstrating both scientific rigor and clinical relevance.