معرفی
Stephanie Gates is an Assistant Professor in the Department of Biochemistry within the College of Agriculture, Food and Natural Resources (CAFNR) at the University of Missouri. Her research focuses on Protein Quality Control (PQC) pathways, specifically investigating molecular chaperones and the Ubiquitin Proteasome System (UPS) in cancer and neurodegenerative disease contexts.
Educational background:
- Ph.D. in Chemical Biology, University of Michigan
Dr. Gates' research integrates cryo-electron microscopy, single-molecule FRET, and biochemical assays to dissect chaperone-proteasome interactions in PQC. Her work addresses critical mechanisms in cancer (where PQC pathways support tumorigenesis through uncontrolled protein expression) and neurodegeneration (involving toxic aggregates like α-synuclein in Parkinson's and Aβ/tau in Alzheimer's). The lab's structural and biophysical approaches aim to identify novel therapeutic targets within these pathways.
The Gates Lab actively recruits new graduate students and investigates how chaperone dynamics regulate substrate degradation, with implications for developing treatments targeting protein-protein interactions in oncology and neurology.
