معرفی
Prof. Stefan Jakobs is a Professor of High-Resolution Microscopy of the Cell at the University of Göttingen Medical School's Department of Neurology and a research group leader at the Max Planck Institute for Multidisciplinary Sciences. His expertise spans mitochondrial biology, super-resolution microscopy, and reversible switchable fluorescent proteins (RSFPs). Jakobs holds a PhD from the University of Cologne (1999) and habilitation in Botany/Cell Biology from Georg-August-University Göttingen (2007). His research focuses on mitochondrial structure and dynamics, particularly their role in neurodegenerative diseases, and improving RSFPs for live-cell imaging. He received an ERC Advanced Grant (2019) for investigating mitochondrial architecture. His work bridges molecular biology, biochemistry, and advanced microscopy techniques like STED and MINFLUX nanoscopy.
Key affiliations include the Max Planck Institute for Biophysical Chemistry and collaboration with the Department of NanoBiophotonics. His lab explores mitochondrial cristae formation, protein clustering (e.g., MICOS complex), and Bax-mediated apoptosis mechanisms. Jakobs' ERC-funded projects aim to elucidate mitochondrial structural maintenance and their implications in disease. He also develops novel imaging probes, such as engineered phytochromes for near-infrared STED microscopy. Collaborations span neurology, biophysics, and surface chemistry, reflecting his interdisciplinary approach to cellular and molecular biology.
