Stefan Bagby

Stefan Bagby is a Reader in the Department of Life Sciences at the University of Bath, affiliated with the Centre for Nanoscience and Nanotechnology and the Centre for Bioengineering & Biomedical Technologies (CBio). He is an active faculty member with a strong research profile in molecular microbiology, immunology, and biophysical biochemistry. His work integrates genomics, structural biology, and nanotechnology to study bacterial pathogenesis and host immune responses.

His research focuses on Staphylococcus aureus and Bordetella pertussis, exploring mechanisms of immune evasion, protein-protein interactions, and post-translational modifications such as lipoylation and palmitoylation. He also investigates cancer immunology, autoantibodies in myositis, and the application of nanopore sequencing and graphene-based biosensors for diagnostics and biotechnological applications.

The recent publications highlight a strong trend in nanopore-based metagenomics for respiratory infection diagnostics, pan-cancer immune gene signatures, and bacterial genomics for understanding pathogen evolution. His work bridges fundamental molecular mechanisms with translational applications in infection, autoimmunity, and cancer.

Scientific Contributions:

• Extensive research on Staphylococcus aureus immune evasion proteins (Efb, Sbi).
• Pioneering use of nanopore sequencing in bacterial genomics and clinical metagenomics.
• Development of graphene-based biosensing platforms using supramolecular enzyme complexes.
• Investigations into autoantibodies in myositis and their clinical implications.

Supervision and Collaboration: He is actively accepting doctoral students and has supervised at least 10 research projects. His interdisciplinary work involves collaborations across biochemistry, immunology, oncology, and nanotechnology.

Laboratory and Facilities: His research is supported by the Centre for Nanoscience and Nanotechnology and CBio, providing access to advanced instrumentation for protein biophysics, genomics, and nanomaterial-based sensing.