معرفی
Sridhar Mani, M.D., is a Professor in multiple departments at Albert Einstein College of Medicine: Oncology (Medical Oncology), Medicine (Oncology & Hematology), Molecular Pharmacology, and Genetics. His research focuses on microbiome-host interactions, orphan nuclear receptors, gastrointestinal cancer, and drug discovery. He investigates how microbial metabolites like indoles and indole propionates activate receptors such as PXR to regulate immune homeostasis and combat inflammation-induced diseases.
Key research areas include designing microbial metabolite mimics as drugs, discovering novel bacterial strains affecting intestinal health, and developing probiotic therapies. His work bridges microbiology, pharmacology, and immunology, with recent emphasis on neuroregeneration via gut metabolites and bacterial swarming dynamics in intestinal stress conditions.
Publications highlight breakthroughs in PXR ligand design, probiotic applications, and the role of indole-3 propionate in nerve repair. His lab employs multidisciplinary approaches combining molecular biology, chemical synthesis, and biophysical modeling. No specific grants or awards are explicitly listed in the text.
Mani’s laboratories are located at the Jack and Pearl Resnick Campus in Bronx, NY, and collaborate extensively with institutions like Imperial College London. His work aims to transform microbial metabolite insights into clinically relevant therapies for gastrointestinal, immunological, and neurological disorders.
