Sophia Yohe

Sophia Yohe, MD, is a Professor in the Department of Laboratory Medicine and Pathology at the University of Minnesota Medical School, Twin Cities. She serves as the Director of the Molecular Diagnostics Laboratory and as Vice Chair for Clinical Strategy in the Division of Molecular Pathology and Genomics.

• Specializes in hematopathology and molecular genetic pathology
• Focuses on implementing genomic testing into clinical practice
• Uses next-generation sequencing (NGS) for inherited conditions and cancer gene mutations

Her research emphasizes improving detection of minimal residual disease (MRD) in hematopoietic malignancies like acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) through genomic and flow cytometric technologies. Yohe collaborates with bioinformatics experts at the Minnesota Supercomputing Institute to advance clinical applications. Her work addresses the heterogeneity of immunophenotypes and genetics in blood cancers, with ongoing efforts to develop novel MRD detection methods.

Yohe is actively involved in clinical strategy and laboratory leadership, bridging genomic research with diagnostic implementation. She works closely with clinical colleagues to demonstrate the importance of MRD assessment pre-transplant in hematopoietic malignancies.