معرفی
Siam Oottamasathien, MD, FAAP, FACS, is an Adjunct faculty member in the Department of Surgery at the University of Utah, where he directs the pediatric urology basic science research program. A board-certified pediatric urologist and principal investigator, he couples clinical expertise with innovative translational research focused on bladder inflammation, fibrosis, and hyaluronic-acid–based therapeutics.
Education & Training
- BA in Molecular Biology & Biochemistry – University of Colorado at Boulder
- MD – University of Colorado School of Medicine
- Urology Residency & Chief Residency – University of Colorado Health Sciences Center
- Pediatric Urology Fellowship – Vanderbilt University
Research Interests
Dr. Oottamasathien’s laboratory integrates developmental biology, biomaterials science, and urologic translational medicine. A central theme is the use of hyaluronic-acid derivatives to modulate inflammatory cascades within the bladder wall. By developing in vivo murine models that recapitulate interstitial cystitis and painful bladder syndrome, his group identifies molecular targets and validates novel anti-inflammatory therapeutics.
His team has pioneered photocrosslinkable hyaluronan-gelatin hydrogels for 3-D bioprinting of bladder constructs, engineered gold-nanoparticle/HA composites for localized drug delivery, and elucidated T-box transcription-factor networks governing genitourinary organogenesis. These efforts bridge bench discoveries to bedside applications, with several patents and an FDA-track small-business partnership (GlycoMira Therapeutics) advancing lead compounds toward clinical trials.
Scientific Awards & Honors
- American Academy of Pediatrics Section on Urology – Basic Science Research Award (2006, 2010, 2012)
- American Urological Association / Pfizer Award – Benign Urologic Disease Research
- Society of Pediatric Urology Early Career Investigator Representative & 2nd Place (AUA 2013)
- Primary Children’s Hospital Early Career Development Award
- Primary Children’s Hospital Integrated Science Award
Funding & Grants
- NIH R01 DK100868 – Glycosaminoglycan derivatives for bladder pain
- NIH K12 UL1RR025764 – University of Utah CCTS Career Development Award
- NIH Phase I SBIR R43DK093413 – GlycoMira Therapeutics collaboration
- NIH T32 HL079874 – Post-doctoral training under Nobel Laureate Dr. Mario Capecchi
- National Kidney Foundation – Utah Chapter grant
- American Urological Association / Pfizer Research Award
Laboratory & Collaborations
Dr. Oottamasathien leads a multidisciplinary team housed within the University of Utah’s Department of Surgery and maintains active collaborations with the Department of Medicinal Chemistry (Glenn Prestwich, PhD). The group integrates murine genetics, biomaterials engineering, and translational pharmacology to accelerate pediatric urologic therapeutics from concept to clinic.
