معرفی
Dr. Shweta Joshi is an Assistant Adjunct Professor in the Department of Pediatrics at the University of California, San Diego School of Medicine. Her research focuses on understanding molecular mechanisms regulating tumor growth, inflammation and metastasis, with special emphasis on neuroblastoma and pancreatic adenocarcinoma.
Dr. Joshi's laboratory investigates signaling cascades that regulate recruitment and activation of immunosuppressive myeloid cells in solid tumors. Her work centers on how Syk kinase signaling influences tumor-associated macrophages and myeloid-derived suppressor cells, and how targeting these pathways can enhance anti-tumor immune responses. She has published extensively on dual-target inhibitors that simultaneously address tumor cell proliferation and immunosuppression in the tumor microenvironment.
Dr. Joshi's recent publications demonstrate expertise in cancer immunology and targeted therapies, with multiple high-impact papers on Syk inhibition in pancreatic cancer and neuroblastoma. Her work shows how reprogramming the tumor microenvironment can overcome resistance to chemotherapy and immunotherapy.
- Perioperative Fostamatinib + Chemotherapy for Resectable Pancreatic Cancer (Cure Bound Cure Prize, 2024-2027) - Co-PI
- Syk-Targeted Therapy with Fostamatinib (Lustgarten Clinical Accelrator Initiative Grant, 2024-2027) - Co-PI
- Targeting Syk to enhance anti-tumor immune responses in neuroblastoma (NIH R01NS122835, 2021-2026) - PI
- Myeloid Syk promotes tumor immunosuppression and inhibits anti-tumor adaptive immunity (NIH K22CA229594, 2019-2022) - PI
Dr. Joshi maintains active collaborations with researchers across UCSD including Donald Durden, Andrew Sharabi, Pablo Tamayo, Timothy Pham, and Alice Yu. Her laboratory bridges basic science discoveries with translational applications to develop novel therapeutic strategies for high-risk solid tumors, particularly focusing on how to overcome tumor immunosuppression in neuroblastoma and pancreatic cancer.
