معرفی
Dr. Shobhan Gaddameedhi is an Associate Professor in the Department of Biological Sciences at NC State University, affiliated with the College of Sciences. Their research focuses on circadian rhythms, UV radiation effects, DNA repair mechanisms, and the health impacts of shift work. They hold affiliations with the Center for Human Health and the Environment (CHHE), Functional Genomics, Genetics, and Integrative Physiology and Neurobiology programs. Dr. Gaddameedhi’s lab explores how circadian disruption influences cancer development, metabolic disorders, and immune responses, particularly in skin carcinogenesis and melanoma biology.
Education details are not explicitly listed in the provided text, but their extensive publication history indicates advanced training in molecular biology and chronobiology. Research interests include: 1) circadian clock regulation of DNA repair pathways, 2) UV-induced skin damage mechanisms, 3) metabolic consequences of shift work schedules, and 4) chronotherapeutic strategies for cancer treatment. Recent work highlights how misaligned circadian rhythms exacerbate DNA damage and insulin dysregulation, with implications for cardiovascular and metabolic health.
Over 60 peer-reviewed articles demonstrate expertise in proteomics, metabolomics, and mouse models to study circadian health effects. Key findings include circadian clock protection against radiation-induced cardiotoxicity and the role of BMAL1 in melanoma progression. Their work bridges basic science and clinical applications, emphasizing time-dependent biology in disease prevention and treatment.
