Shekhar Singh

Shekhar Singh is a Doctoral Researcher at the A.I. Virtanen Institute for Molecular Sciences, part of the Faculty of Health Sciences at the University of Eastern Finland. His work focuses on the molecular mechanisms of Progressive Myoclonic Epilepsy Type 1 (EPM1), particularly the role of the Cystatin B (CSTB) gene and protein in neurodevelopment. He contributes to the Neuro-Innovation project (2021–2026), which investigates pathophysiological pathways of rare neurological disorders.

• Education: Not explicitly stated but implied through doctoral researcher status.
• Projects: Neuro-Innovation (2021–2026).

His research explores CSTB's multifaceted roles in proteostasis, mitochondrial function, neuroinflammation, and GABAergic neuron regulation. He uses human cerebral organoids and mouse models to study how CSTB mutations cause neuronal dysfunction and neurodegeneration in EPM1. Key findings include CSTB's interaction with histones, cathepsins, and Kif1a to control cell cycle, oxidative stress, and interneuron migration.

Recent publications highlight his expertise in molecular genetics and neurodevelopmental disorders. He collaborates with Riikka H. Hämäläinen on EPM1 studies, funded by the University of Eastern Finland and the European Union’s Horizon 2020 (Marie Skłodowska-Curie grant 101034307).