معرفی
Shashirekha Shetty, PhD, serves as Associate Professor in the Department of Pathology at Case Western Reserve University School of Medicine. Externally, she holds dual leadership roles at University Hospitals: Director of the Cytogenetics Laboratory at the Center for Human Genetics Laboratory and Associate Director of the Laboratory Genetics and Genomics (LGG) Fellowship Program. Her office is located on the 6th floor of the Walker Building.
As a board-certified clinical cytogeneticist and molecular geneticist, Dr. Shetty specializes in cytogenomics and molecular diagnostics for both germline and somatic conditions. Her primary clinical focus involves developing non-invasive prenatal screening (NIPS) assays using panel-based testing to evaluate genes linked to ultrasound-detected fetal structural abnormalities. Research collaborations center on characterizing human model cell lines to decipher disease mechanisms. The cytogenomics laboratory under her direction employs chromosome karyotyping, fluorescence in situ hybridization (FISH), and genomic chromosomal microarrays to detect balanced structural and unbalanced copy number changes, while the molecular laboratory utilizes next-generation sequencing (NGS) for comprehensive genomic profiling.
Analysis of her publication record reveals a strong emphasis on cancer genomics, with research spanning acute myeloid leukemia, breast cancer, mantle cell lymphoma, and multiple myeloma. Her work consistently bridges diagnostic cytogenetics with molecular pathology to address clinical challenges in oncology and prenatal genetics, demonstrating translational applications of genomic technologies in disease characterization and biomarker discovery.
No scientific awards were mentioned in the provided text.
The text does not specify any graduate students, postdoctoral advisees, or research grants under Dr. Shetty's direct supervision. Her laboratory infrastructure at University Hospitals serves as a critical resource for genomic characterization, providing clinically validated data that supports both diagnostic operations and collaborative research initiatives.
Dr. Shetty's laboratory ecosystem integrates cytogenomics and molecular diagnostics workflows, featuring dedicated facilities for karyotyping, FISH analysis, chromosomal microarray processing, and NGS-based testing. This infrastructure enables comprehensive genomic characterization that informs clinical decision-making while generating high-quality data for translational research partnerships across oncology and prenatal medicine domains.