Shannon Miller

Shannon Miller, Ph.D., is an Assistant Professor in the Department of Chemistry at Scripps Research, with joint appointments in Immunology & Microbiology and the Skaggs Graduate School of Chemical and Biological Sciences. Her research focuses on developing technologies for in vivo genome editing to treat genetic diseases. Key areas include AAV vector engineering, large DNA manipulation methods, and CRISPR therapeutic optimization using chemically modified sgRNAs.

Education:

• Ph.D. (Chemistry and Chemical Biology), Harvard University, 2022
• B.S. (Chemistry), University of Illinois Urbana-Champaign, 2016

Research Interests: Miller’s lab addresses challenges in genome editing’s toxicity, delivery, and DNA manipulation scope. They combine chemistry and biology to improve AAV vectors for industrial use, enable large-scale DNA edits, and enhance CRISPR safety via chemically modified sgRNAs.

Notable Achievements: Miller has received prestigious awards such as Forbes 30 Under 30 (2022) and the NSF Graduate Research Fellowship (2016–2019). Her work spans publications in Nature, Nature Biotechnology, and Nature Protocols, focusing on CRISPR innovation and therapeutic applications.

Lab & Collaborations: The Miller Lab collaborates across disciplines to advance in vivo biomolecule therapeutics. Their efforts aim to translate genome editing into clinical solutions for genetic disorders like sickle cell disease.