Seppo Helisalmi

Seppo Helisalmi is a Staff Scientist at the Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences, University of Eastern Finland. His research centers on neurodegenerative diseases, with a focus on Alzheimer's disease, frontotemporal dementia, and idiopathic normal pressure hydrocephalus. He employs genetic, metabolomic, and biomarker-driven approaches to investigate disease mechanisms and diagnostic strategies.

Helisalmi's research interests span:

• Genetic Epidemiology: Genome-wide studies of Alzheimer's risk variants and their pathological implications.
• CSF Biomarkers: Validation of amyloid-β, tau, and TDP-43 as diagnostic and prognostic tools.
• Metabolic Dysregulation: Metabolite profiling in dementia progression and comorbidities like diabetes.

His publications predominantly explore genetic and biomarker correlates of neurodegeneration. Recent works emphasize large-scale meta-analyses, population genetics in Finnish cohorts, and clinical trials (e.g., LipiDiDiet). A consistent focus is the interplay between genetic mutations (e.g., C9orf72, SORL1) and biochemical pathways in dementia.

He contributes to collaborative projects, including the Genome Center of Eastern Finland (GCEF) and UEF Brain Research Unit 2.0, enhancing regional research infrastructure in neuroscience.