Sebastian Canzler

Dr. Sebastian Canzler is the Head of the Computational Systems Biology group at the Helmholtz Centre for Environmental Research (UFZ) in Leipzig, Germany. He is affiliated with the Department of Computational Biology & Chemistry and contributes to projects such as multiGSEA software development, XomeTox, and chemical grouping frameworks.

• Education: Diploma & PhD in Bioinformatics (University of Leipzig, 2011 & 2017)
• Professional Roles: PostDoc (University of Leipzig, 2017); PostDoc & Head (UFZ, 2018–Present)

Research Interests: His work focuses on multi-omics data integration for chemical risk assessment, pathway enrichment analysis, single-cell transcriptomics in systems toxicology, and development of FAIR data management practices. He specializes in refining adverse outcome pathways (AOP) and applying explainable AI to predict chemical effects.

Scientific Trends: Recent publications emphasize thyroid toxicity mechanisms, retinal organoid modeling, and computational frameworks for evaluating chemical mixtures. His software tools (multiGSEA, ProteinPrompt) address pathway analysis and protein interaction prediction.

Collaborations: Works with Prof. Jörg Hackermüller, Prof. Martin von Bergen, and teams across bioinformatics, ecotoxicology, and exposure science.