Scott L. Nyberg

Scott L. Nyberg, M.D., Ph.D., is a Professor of Biomedical Engineering and Surgery at Mayo Clinic in Rochester, Minnesota. He serves as the Director of the Mayo Clinic Liver Support Program and leads the Mayo Clinic Liver Regeneration Program, focusing on innovative therapies for liver failure and transplantation.

Education:

• Doctor of Philosophy (Biomedical Engineering), University of Minnesota
• M.D., The Johns Hopkins University School of Medicine
• B.S. (Chemical Engineering), Massachusetts Institute of Technology
• Residency and Fellowship in General and Transplant Surgery, University of Minnesota

Dr. Nyberg's research centers on regenerative medicine and bioartificial liver development. His lab pioneers extracorporeal systems like the Mayo Spheroid Reservoir Bioartificial Liver, utilizing porcine hepatocytes and genetically engineered HT1 pigs as in vivo incubators for human hepatocytes. His work spans tissue engineering, hepatocyte transplantation, and metabolic liver disease treatment, aiming to create a 'humanized' bioartificial liver for clinical use. His research is highly translational, aiming to bridge liver failure patients to transplantation or recovery.

His 15 most recent publications reflect a sustained focus on liver regeneration, stem cell therapies, decellularized scaffolds, and imaging techniques. These works demonstrate interdisciplinary innovation across biomedical engineering, transplantation, and regenerative medicine, with increasing emphasis on iPSCs, immune modulation, and bioengineered grafts.

Scientific Awards and Honors:

• Yardi Professor of Transplantation (2023)
• America's Best Physicians (2021)
• Albert Nelson Marquis Lifetime Achievement Award (2017)
• Coulter Translational Research Award (2011–2013)
• ASTS/Pfizer Collaborative Research Award (2012–2014)
• Multiple early-career awards in surgery and artificial organs

Dr. Nyberg has held significant leadership roles, including Chair of the Surgical Research Committee at Mayo Clinic (2000–2011), adviser to the FDA, and co-chair of NIH workshops. He holds multiple patents in bioartificial liver devices and genetically modified pigs. His lab serves as a multidisciplinary hub for trainees and collaborators, fostering innovation in transplantation and regenerative biotherapeutics.

Laboratories and Programs:

• Mayo Clinic Liver Regeneration Program
• Mayo Clinic Liver Support Program
• Director, Surgical Research Committee (past)
• Medical Director, Office of Clinical Research, Department of Surgery (since 2003)