Saurabh Chattopadhyay

Saurabh Chattopadhyay is an Associate Professor at the University of Kentucky in the Microbiology, Immunology, and Molecular Genetics unit. He holds a PhD in Biotechnology from the Indian Institute of Technology Delhi and completed postdoctoral training in Viral Immunology at the Cleveland Clinic.

Education

• B.Sc in Chemistry, University of Calcutta
• M.Sc in Biochemistry, University of Calcutta
• PhD in Biotechnology, Indian Institute of Technology Delhi
• Postdoctoral Fellowship in Viral Immunology, Cleveland Clinic

Research Interests

Dr. Chattopadhyay's research focuses on host-virus interactions, particularly the role of interferon regulatory factors (IRF3, IRF7) and NF-κB in innate immunity. His lab investigates:

• Molecular mechanisms of type-I interferon signaling
• Phosphorylation and ubiquitination of immune transcription factors
• High-throughput screening for antiviral genes and drugs
• Role of autophagy in viral infection
• Mouse models of viral pathogenesis

Publications

His recent work spans innate immunity, interferon signaling, viral inflammation, and host-targeted antivirals, with studies on:

• IRF3-NF-κB crosstalk in macrophages
• TLR9 phosphorylation mechanisms
• Interferon-stimulated gene TDRD7
• 14-3-3ζ in cytokine signaling
• Autophagy inhibition in viral infection
• SARS-CoV-2 wastewater surveillance

Laboratory

The Chattopadhyay Lab employs engineered cell lines and mouse models to dissect antiviral pathways, with a focus on therapeutic targets for respiratory viruses and coronavirus variants.