Sarosh Irani

Sarosh Irani is a Clinician-Scientist and Consultant Neurologist at the University of Oxford, affiliated with the Nuffield Department of Clinical Neurosciences. He collaborates with the Oxford Autoimmune Neurology Group and serves as an Associate Editor for Brain, a leading journal in neurology.

Research Interests

His work focuses on autoantibody-mediated neurological diseases, investigating the interplay between patient-specific phenotypes and immunological mechanisms. Key areas include:

• Discovery of novel autoantibodies (e.g., LGI1, CASPR2)
• Genetic associations (HLA) in autoimmune diseases
• B cell dynamics and immune tolerance breaks
• Monoclonal antibody development for neuroscience research

Recent publications emphasize neuroimmunology, autoantibody pathogenicity, and immunotherapy strategies for conditions like neuromyelitis optica and NMDA receptor-antibody encephalitis.

Scientific Awards

• Royal College of Physicians: Graham-Bull Prize in Clinical Science, Goulstonian Lectureship
• NIHR BRC Senior Clinical Fellowship
• Wellcome Intermediate Fellowship
• MRC Senior Clinical Fellowships

Funding and Collaborations

His research is supported by grants from the British Medical Association, Association of British Neurologists, industry partners, and patient donations. He actively recruits clinicians and scientists to join his team at Mayo Clinic, Florida, where his lab has relocated.