Sarah Mahdally

Sarah Mahdally, DO, serves as an Assistant Professor in the Department of Pediatrics with research expertise spanning neonatal immunology, gut microbiome dynamics, and critical care transitions. Her work focuses on vulnerable preterm infant populations, particularly examining how secretory immunoglobulin A (SIgA) interactions with intestinal microbiota influence inflammatory responses and barrier maturation.

Dr. Mahdally's research program centers on the neonatal gut-immune interface, investigating molecular mechanisms where SIgA binding modulates microbiota composition to attenuate inflammatory reactions during intestinal barrier development in preterm infants. This work bridges basic immunological principles with clinical neonatology to address complications like necrotizing enterocolitis and systemic inflammation.

Her recent publications reveal a strategic research trajectory advancing from fundamental gut-immune mechanisms (2023) toward clinical applications including congenital hyperinsulinism screening protocols (2024) and critical care transition systems (2025). This progression demonstrates translational rigor connecting laboratory discoveries to neonatal intensive care unit (NICU) practice improvements and patient transfer protocols between critical care settings.