Sandy Y. Chang

Dr. Sandy Y. Chang is an Assistant Professor in the Department of Medicine at Loma Linda University School of Medicine. She leads clinical research in infectious diseases and transplantation, with active roles in multicenter trials and institutional studies. Her work spans HIV prophylaxis, COVID-19 therapeutics for immunocompromised patients, and predictive biomarkers for transplant rejection.

Research Focus: Dr. Chang investigates virology and immunology in high-risk populations, including solid organ transplant recipients. Key areas include cytomegalovirus (CMV) pathogenesis, T-cell alloreactivity in kidney transplants, and novel antiretroviral strategies for HIV prevention.

Grants & Projects: She currently oversees:

• A Phase 3 HIV prevention study using long-acting lenacapavir (Gilead Sciences, 2024–2025)
• CMV infection risk/outcome analysis in transplant recipients (LLU, 2023)
• COVID-19 monoclonal antibody efficacy in transplant patients (LLU, 2023)
• Predictive modeling of kidney transplant rejection via T-cell clones (LLU, 2023–2026)
• Regulatory T-cell integration with donor DNA for graft monitoring (ASTS, 2024–2025)

She also contributes to the Loma Linda International Surveillance Network (LLISN) for global disease tracking.