S. Mohammad H. Shafie

S. Mohammad H. Shafie, MD, PhD serves as an Associate Professor in the Department of Neurology at the University of California, Irvine School of Medicine. His clinical and research focus centers on acute stroke interventions within comprehensive stroke care systems.

His primary research domains include:

• Intracranial atherosclerotic disease management
• Rescue therapies for failed mechanical thrombectomy
• Door-to-needle time optimization for thrombolysis
• Vertebrobasilar occlusion treatment protocols

Analysis of his publications reveals consistent focus on procedural innovations for large vessel occlusion strokes, particularly addressing challenges in intracranial stenosis cases where conventional thrombectomy fails. His work bridges interventional neuroradiology techniques with acute stroke pharmacotherapy.

Dr. Shafie actively participates in clinical trial design for stroke reperfusion therapies, with emphasis on real-world implementation of time-sensitive treatments in emergency settings. His quality improvement research demonstrates measurable reductions in treatment delays without compromising safety.