Róisín McManus

Dr. Róisín McManus is a Group Leader within the Career Development Fellow Programme at the German Center for Neurodegenerative Diseases (DZNE) in Bonn. She is associated with the Institute of Innate Immunity and conducts research on microglial immune signaling and metabolic changes in neurodegenerative diseases, particularly Alzheimer's disease.

• Research Focus: Innate immune response, immunometabolism, and environmental factors (e.g., Western diet) in neuroinflammation
• Methodology: Experimental and multi-omic approaches using transgenic animal models, primary cultures, human iPSCs, and clinical samples

In 2024, her work highlighted the role of the microglial NLRP3 inflammasome in Alzheimer's disease progression. Her research aims to identify novel immune-targeted therapies for patient-specific treatment of inflammatory and neurodegenerative conditions.