Ryan T. Brennan

Ryan T. Brennan, DO serves as an Assistant Professor in the Department of Neurology at the Medical College of Wisconsin. He directs the Deep Brain Stimulation & Specialized Treatments program and co-directs the Parkinson's Foundation Comprehensive Care Center and Movement Disorders Section. His clinical work focuses on movement disorders including Parkinson disease, dystonia, and essential tremor, with expertise in botulinum toxin injections and deep brain stimulation.

• Education: DO from Michigan State University College of Osteopathic Medicine (2011)
• Training: Neurology residency and chief residency at MCW (2012-2015), Movement Disorders fellowship at University of Nebraska Medical Center (2015-2017)

Dr. Brennan's research centers on movement disorders, particularly Parkinson disease management, deep brain stimulation optimization, and novel therapeutic approaches. His work examines DBS programming protocols, Parkinson's disease biomarkers, and non-pharmacological interventions like exercise and focused ultrasound. He leads multiple clinical trials investigating new Parkinson's treatments including CVN424 and lenrispodun therapies.

His recent publications reveal strong focus on deep brain stimulation techniques, Parkinson disease therapeutics, and movement disorder genetics. Key trends include optimizing DBS programming, investigating novel Parkinson's treatments, and exploring genetic factors in movement disorders like Perry syndrome.

• Dr. Gregory J. Harrington Award for Outstanding Service in Neurology (2015)
• Jon Gudeman Golden Apple Teaching Award (2025)

As Associate Program Director for the Movement Disorders Fellowship, Dr. Brennan mentors neurology fellows and medical students. He leads multiple NIH and industry-funded clinical trials including PD GENEration, CVN424 studies, and NEU-411-PD201. His grant portfolio includes principal investigator roles for the Daniel M. Soref Charitable Trust Fellowship and TARGET-PD trial examining objective Parkinson's measurement.

Dr. Brennan co-directs the Parkinson Foundation Comprehensive Care Center and MCW's MRI Guided Focused Ultrasound Program. He leads the Deep Brain Stimulation & Specialized Treatments team while developing teleconsult services for neurological care.