Ruchi Shukla

Ruchi Shukla is a Researcher at Northumbria University, specializing in cancer biology with a focus on retrotransposon-driven mechanisms in hepatocellular carcinoma (HCC) and autoimmune diseases. She holds a PhD in Biological Sciences (2007) and has led groundbreaking studies on L1 retrotransposon activation in cancer initiation and progression. Her work bridges molecular oncology, immunology, and genetic instability, with key contributions to understanding HCV-induced carcinogenesis and synthetic lethality targets in HCC.

Research Interests:

• Retrotransposon mobilization in cancer development
• Molecular pathways in hepatocellular carcinoma
• Autoimmune mechanisms and cytokine networks
• Tumor microenvironment dynamics
• Therapeutic targets for non-cirrhotic HCC

Publications Highlight:

Her most recent work (2025) links retroelement activation to anti-CCP antibodies in rheumatoid arthritis, while her 2023 studies identify TIAM1 as a synthetic-lethal target in HCC. Over 20 peer-reviewed articles span retrotransposon biology, cancer genetics, and viral oncogenesis.

Advising & Collaboration:

Supervises Ayodeji Olushola Awotula (PhD student since 2024). Collaborates with global teams on projects involving epigenetic regulation, biomarker discovery, and translational oncology.

Labs/Teams:

Conducts research within Northumbria's interdisciplinary cancer biology group, focusing on genomic instability and tumor biology.