Ruben Bierings

Ruben Bierings is an Associate Professor in the Department of Hematology at Erasmus MC, Faculty of Medicine. His research focuses on molecular and cellular mechanisms underlying bleeding disorders, particularly those involving von Willebrand factor and endothelial cell biology.

His primary research interests include:

• Von Willebrand Factor biosynthesis and secretion
• Weibel-Palade body exocytosis
• Endothelial cell dysfunction in hemostasis
• Genetic variants in von Willebrand disease
• Novel therapeutic strategies including siRNA-based treatments

Recent publications highlight a strong trend in understanding the pathophysiology of von Willebrand disease through patient-derived and gene-edited models, as well as evaluating clinical responses to therapies like DDAVP. His work integrates proteomics, cell biology, and translational hematology, contributing significantly to the diagnosis and treatment of thrombocytopathies and coagulation disorders.

Ruben Bierings has held previous external positions as a Group Leader and Senior Postdoc at Sanquin Research and Landsteiner Laboratories, and was a CDF Postdoctoral Fellow at the MRC National Institute for Medical Research. These roles reflect a deep engagement with blood-related research institutions and collaborative networks in hematology.

He is actively involved in supervising research, with contributions to multiple doctoral theses and collaborative projects such as the SYMPHONY consortium and the Thrombocytopathy in the Netherlands (TiN) Study Group. Although no specific grants are listed, his participation in large consortia suggests involvement in funded research programs.

Ruben Bierings contributes to a vibrant research ecosystem centered on vascular biology and hemostasis, working closely with teams at Erasmus MC and external partners such as Sanquin and academic collaborators across Europe.