Roger S. Lo

Dr. Roger S. Lo is a Professor at the University of California, Los Angeles (UCLA) with joint appointments in Dermatology, Medicine, and Molecular & Medical Pharmacology. He serves as Director of the Melanoma Clinic in Dermatology and Associate Chief of Dermatology at UCLA Health.

• Key affiliations:
  • Dermatology STAR Residency Program
  • Genetics & Genomics GPB Home Area
  • JCCC Signal Transduction and Therapeutics Program
  • Molecular Pharmacology GPB Home Area

His research focuses on melanoma biology, cancer drug resistance mechanisms, and targeted immunotherapy strategies. With dual MD/PhD training, he bridges clinical practice and molecular pharmacology research.

Recent research trends include:

• Genomic instability and ecDNA formation in resistance development
• Immune checkpoint regulation (PD-L1/L2) during therapy
• MAPK signaling pathway manipulation for treatment optimization
• Multi-organ dynamics of therapy-resistant melanoma

Dr. Lo has contributed to significant clinical trials like SWOG S1320 (BRAF/MEK inhibitor dosing) and developed CRISPR-CATCH for extrachromosomal DNA analysis.

His work extends to understanding BRAF inhibitor-induced cutaneous effects and metabolic reprogramming in resistant cancers.