Rita Alaggio

Rita Alaggio is a Full Professor at the Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome. She specializes in pediatric oncology, sarcoma research, and molecular pathology, with a focus on diagnostic biomarkers, genomic profiling, and epigenetics. Her work is conducted in collaboration with international consortia such as GIPAD-GIPPI, IPSO, CHIC, and EpSSG.

Her research emphasizes:

• Molecular characterization of pediatric sarcomas and neuroendocrine tumors
• Epigenetic profiling for tumor classification (e.g., DNA methylation in MPNST and DICER1-associated tumors)
• Development of AI models for histopathological analysis
• Identification of novel gene fusions (SH3PXD2B::FER, ZFTA-fusion) in rare tumors
• Clinical implications of genetic aberrations (ALK, BCOR, YWHAE)

Recent publications highlight trends in:

• Protein kinase-related mesenchymal tumors with EGFR domain duplications
• GD2-targeted immunotherapies for medulloblastoma
• Diagnostic challenges in spindle/sclerosing rhabdomyosarcoma subtypes

She contributes to consensus classifications (WHO Hematolymphoid Tumours) and surgical margin harmonization (INSTRuCT). No specific scientific awards or student advisees are mentioned in the provided texts.