معرفی
Richard C. Holz is a Professor of Chemistry at the Colorado School of Mines. His research focuses on bioinorganic chemistry, mechanistic enzymology, and biophysical chemistry, particularly studying metalloenzymes as industrial catalysts and antimicrobial targets. His group employs biochemical and biophysical techniques like enzyme kinetics, site-directed mutagenesis, and spectroscopy.
Education:
- BS, Bemidji State University
- MS, University of Minnesota-Duluth
- PhD, Pennsylvania State University
- Postdoctoral Fellow (NIH), University of Minnesota
Research Highlights: Current projects include NSF-funded studies on nitrile hydratase (NHase) catalytic mechanisms and dehalogenase-based bioremediation. Key areas include enzyme maturation, metalloenzyme coordination chemistry, and environmental contaminant degradation using catalytic biomaterials.
Funding: Active NSF grant (CHE-1808711) supports collaborative research on NHase mechanisms and applications in biocatalyst development. Projects emphasize industrial applications (e.g., acrylamide production) and environmental cleanup.
Labs/Teams: The Holz research group develops novel biomaterials for contaminant degradation and investigates enzyme mechanisms using advanced spectroscopic methods like EPR and NMR.
