Renata Sigrist

Renata Sigrist is a Staff Scientist at the Novo Nordisk Foundation Center for Biosustainability, affiliated with the DTU Microbes Initiative at the Technical University of Denmark. Her research focuses on microbiology, biochemistry, and biotechnology, particularly the biosynthesis of natural products and metabolic engineering in Streptomyces species. She contributes to the UN Sustainable Development Goals through innovations in bioprospecting and synthetic biology.

• Research Keywords: Gene Clusters, Terpenoids, Indole Metabolism, Regulatory Networks, Heterologous Expression, Bioinformatics

Her recent work applies machine learning to decode transcriptional regulation in Streptomyces albidoflavus and explores bifunctional enzymes for novel cytotoxic compound production. She collaborates extensively in pharmacology, toxicology, and immunology domains.

• Scientific Contributions: 15+ peer-reviewed articles, including studies on proteasome inhibitors, isoprenoid pathways, and genetic tools for Streptomyces.

Based at the DNA Foundry and Strain Design Teams, her work integrates genome mining, molecular networking, and enzyme engineering to advance sustainable biotechnology solutions.