معرفی
Ramakrishna Kommagani is an Associate Professor in the Department of Pathology at Baylor College of Medicine, Houston, US. His research focuses on understanding molecular mechanisms underlying gynecological disorders, particularly endometriosis, endometrial cancer, and uterine physiology. He leads projects investigating the role of gut microbiota, RNA splicing, and autophagy in reproductive health.
Education: PhD in Biomedical Sciences from Wright State University (Dayton).
Research Interests:
- Endometriosis pathogenesis and microbiota interactions
- RNA splicing factors in gynecological cancers
- Autophagy pathways in uterine development
- Progesterone signaling in endometrial function
Recent work highlights the bidirectional relationship between gut microbiota and endometrial disease progression, as well as the critical role of SF3B1 splicing factors in tumor growth. Studies on autophagy proteins like ATG14 and Beclin-1 reveal their importance in embryo implantation and pregnancy maintenance.
Current projects explore:
- Microbiome-derived metabolites as diagnostic biomarkers
- Targeting RNA splicing for endometrial cancer therapies
- Autophagy's dual role in stem cell programming and inflammation
Laboratory focuses on translational research combining mouse models, CRISPR screens, and human tissue studies to bridge basic science and clinical applications in reproductive medicine.
