Raif S. Geha

Raif S. Geha is the James L. Gamble Professor of Pediatrics at Harvard Medical School and leads the Division of Immunology at Boston Children's Hospital. With a medical degree from the American University of Beirut and clinical training at Boston Children's Hospital, he is board-certified in Pediatrics, Allergy & Immunology.

• Medical School: American University of Beirut (1969)
• Internship: American University of Beirut (1969)
• Residency: Boston Children's Hospital (1971)
• Fellowship: Boston Children's Hospital (1974)

Research Focus: Dr. Geha's work explores immune dysregulation in genetic disorders, particularly primary immunodeficiencies (e.g., RAG, DOCK8, LRBA, WIP deficiencies). His studies investigate cytokine signaling (IL-4, IL-17, IL-22), Treg and B-cell dysfunction, and skin inflammation mechanisms in diseases like atopic dermatitis and Omenn syndrome.

Scientific Contributions: Over 50 years, his team identified genetic causes of immune disorders (e.g., TFRC, NFKB2, CORO1A mutations), developed diagnostic criteria, and tested therapies like IFN-? and hematopoietic stem cell transplantation. His work bridges clinical immunology with molecular discoveries in Science, Nature, and J Allergy Clin Immunol.