معرفی
Dr. Rafael Guimaraes da Silva is a Senior Lecturer at the School of Biology, University of St Andrews. His research focuses on enzymatic mechanisms, particularly in bacterial histidine and 5-aminolevulinic acid biosynthesis, and human protein histidine phosphorylation. He employs biochemistry and physical chemistry techniques to study transition-state structures and protein dynamics in catalysis.
Education:
- D.Sc. in Biochemistry (2008), Universidade Federal do Rio Grande do Sul, Brazil
- Postdoctoral Training (2008-2012), Albert Einstein College of Medicine, USA
- Principal Scientist (2012-2014), Pfizer, USA
Research Interests:
- Enzyme catalysis
- Protein dynamics
- Transition-state analysis
- Enzyme inhibition and drug design
Grants & Projects:
- Unravelling structure and function of tRNA methyltransferases NSUN2 and METTL1 (Cunningham Trust, 2022-2025)
- Biocatalytic synthesis of targeted nucleotide analogues (EPSRC, 2023-2024)
- Optical tweezers-confocal microscope (BBSRC, 2023-2024)
Labs & Affiliations:
- Based at the Biomedical Sciences Research Complex, University of St Andrews
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