Rémi Buisson

Rémi Buisson, PhD, is an Associate Professor in the Department of Biological Chemistry at the University of California, Irvine (UCI) School of Medicine. His research focuses on the BRCA2 tumor suppressor, DNA replication fork dynamics, and mechanisms of genome instability in cancer. He investigates how BRCA2 interacts with replication factors like MCM10 to suppress PRIMPOL-mediated repriming, a process critical for DNA repair after damage.

• Key Research Themes:
  • DNA Damage Response
  • Replication Fork Stability
  • Homologous Recombination
  • Tumor Suppression Mechanisms

Recent Articles (Trends): His work spans DNA repair pathways, APOBEC enzyme activity in cancer and viral infections, replication stress responses, and circular RNA roles in leukemias. High-impact studies include mechanisms of BRCA2-MCM10 interactions (2021), APOBEC3A's role in therapy resistance (2023), and CRISPR-Cas9 screens for viral RNA decay pathways (2024).

Grants: Funded by multiple NIH/NCI awards including R00 CA212154, R01 CA138804, and P01 CA250957.