Quentin Diot

Quentin Diot, PhD, is Associate Professor in the Department of Radiation Oncology at the University of Colorado Anschutz Medical Campus, School of Medicine, and a member of the University of Colorado Cancer Center. His research integrates medical physics with advanced radiation therapy techniques, emphasizing functional imaging, stereotactic body radiation therapy (SBRT), and the development of ultra-high dose-rate (FLASH) radiotherapy platforms.

Research Focus:

• Functional avoidance radiation therapy using 4DCT-ventilation and PET imaging to spare lung and cardiac function.
• Normal-tissue dose-response modeling for dysphagia, xerostomia, pneumonitis, and cardiac toxicity.
• Design and testing of compact pulse-line ion accelerators (PLIA) for low-cost FLASH radiotherapy and PET isotope production.
• Automation of treatment planning workflows, including knowledge-based planning and TBI plan generation.

Dr. Diot’s prolific publication record (49 peer-reviewed articles) spans 2012-2024 and highlights multi-institutional clinical trials, preclinical accelerator development, and pioneering imaging biomarkers that guide personalized radiation delivery.

Clinical & Translational Impact: His work on functional imaging has laid groundwork for prospective clinical trials aiming to reduce radiation-induced morbidity, while his accelerator research seeks to make FLASH radiotherapy accessible through affordable, novel linear accelerator designs.