معرفی
Pratul Agarwal is a Professor in the Department of Physiological Sciences at Oklahoma State University (OSU), where he also serves as Associate Vice President for Research (Cyberinfrastructure) and Director of the High-Performance Computing Center since 2019. Previously, he held roles at Oak Ridge National Laboratory (2005-2018) and the University of Tennessee (2012-2019). With a Ph.D. in Computational Biochemistry from Pennsylvania State University (2002) and an MSc in Biochemical Engineering from IIT Delhi (1997), his work bridges biochemistry, computational biology, and high-performance computing (HPC).
Agarwal’s research focuses on enzyme catalysis, genomic surveillance for pandemic prediction, and HPC infrastructure. His group develops hybrid computational-experimental methods to study protein structure-dynamics-function relationships, particularly in antibiotic resistance enzymes and redox regulators like BLVRB and APE1. He co-created the OSU Pandemic Prediction Dashboard for real-time SARS-CoV-2 surge forecasting.
His 15 most recent publications (2019-2025) span enzyme dynamics (β-lactamases, Rev1, TERT), computational genomics (SARS-CoV-2 mutations), and metalloprotein mechanisms (LPMO, APE1). These leverage molecular dynamics, QM/MM simulations, and machine learning to dissect catalytic pathways and design inhibitors.
Awards:
- Distinguished Contributor Award, ORNL (2011)
- Outstanding Paper Award (2010)
- Key Contributor Award (2010)
Agarwal has secured grants from NASA, National Institutes of Health (NIH), and National Science Foundation (NSF) for HPC infrastructure, multiscale modeling of enzymes, and pandemic prediction systems. He mentors interdisciplinary collaborations with structural biologists, enzymologists, and computational scientists globally.
