Prashant Mali

Prashant Mali is a Professor in the Department of Bioengineering at the University of California, San Diego. His research bridges genome engineering, RNA biology, and biomedical applications, with a focus on CRISPR-Cas systems and ADAR-mediated RNA editing.

• Education: Ph.D. in Bioengineering
• Key Affiliations: UC San Diego, Altman Clinical and Translational Research Institute

Dr. Mali's work centers on CRISPR-Cas9 technology, RNA editing, and human pluripotent stem cells. His lab develops tools for programmable gene regulation, synthetic lethal screens, and metabolic pathway analysis in disease contexts.

Recent publications highlight innovations in circular RNA engineering, ADAR activity mapping, and metabolic reprogramming in cancer. His team employs multi-omics approaches and in vivo models to translate genome editing into clinical applications.

Students and Collaborators

• Current Lab Members: Sami Nourreddine (Postdoc), Amir Dailamy (Graduate), Andrew Portell (Graduate), Michael Tong (Graduate)
• Alumni: Kyle Ford (PhD 2022), Nathan Palmer (PhD 2022), Udit Parekh (PhD 2021)

Research Themes

• CRISPR Screens: Synthetic lethal interactions, oncogenic pathways, metabolic vulnerabilities
• RNA Editing: ADAR engineering, circular guide RNAs, clinical translation
• Tissue Engineering: Vascularized organoids, cardiac maturation, ex vivo models