Piotr Sliz

Dr. Piotr Sliz serves as an Associate Professor in Pediatrics and in Biological Chemistry and Molecular Pharmacology at Harvard Medical School, with primary affiliation at Boston Children's Hospital. He leads hospital-wide research computing initiatives and directs the Manton Center for Orphan Disease Research programs.

His research spans structural biology, non-coding RNA regulation, and computational genomics, with focus on orphan diseases and rare pediatric conditions. Key methodologies include cryo-EM, bioinformatics, and genomic data integration across international consortia. His work bridges basic structural biology with clinical applications through initiatives like Pediatric Scholar and Children's Rare-Disease Cohorts.

Dr. Sliz founded and leads SBGrid, a global structural bioinformatics consortium facilitating software development and computational infrastructure for structural biologists worldwide. His leadership extends to the Longwood-wide CryoEM computing effort and bioinformatics consulting services at Boston Children's Hospital.

His publication portfolio demonstrates consistent contributions to structural biology, RNA regulation mechanisms, and pediatric genomics, with recent emphasis on global capacity building (BioStruct-Africa) and precision health partnerships for rare diseases. The work shows strong translational focus from molecular mechanisms to clinical implementation.

As leader of hospital-wide research computing since 2016, he has developed critical infrastructure for genomic data access and analysis, directly impacting rare disease diagnosis and outcomes. His SBGrid consortium represents a major international effort in structural biology resource sharing.