Peter Z. Qin

Professor Peter Z. Qin is a faculty member in the Department of Chemistry at the University of Southern California (USC), affiliated with the USC Dornsife College of Letters, Arts and Sciences. His research focuses on understanding nucleic acid recognition mechanisms, genome engineering, and CRISPR-Cas systems, employing advanced techniques like Site-Directed Spin Labeling (SDSL) and electron paramagnetic resonance (EPR) spectroscopy. Qin earned his Ph.D. from Columbia University (1999) and B.S. from Peking University (1991).

Research interests include structural dynamics of nucleic acids, protein-nucleic acid interactions, and CRISPR-mediated DNA cleavage mechanisms. His work bridges physical chemistry and biochemistry, with applications in diagnostics, therapeutics, and gene editing. Notable contributions involve elucidating CRISPR-Cas9 and Cas12a mechanisms, DNA-unwinding checkpoints, and the role of bridge helices in target discrimination.

Recent publications (2021–2025) emphasize CRISPR-Cas systems, DNA dynamics, EPR-based instrumentation, and molecular mechanisms of genome editing. His group develops tools like dual-mode EPR spectrometers and phosphorothioate-based RNA labeling techniques. The lab actively publishes in high-impact journals and collaborates on translational projects like CRISPR-engineered mouse models.

Prof. Qin’s work is supported by grants and collaborations, though specific funding details are not listed. His lab maintains a dedicated website detailing ongoing research and methodologies.