معرفی
Peter McPherson, PhD, is a Professor in the Department of Neurology and Neurosurgery at McGill University's Faculty of Medicine and Health Sciences. He is based at the Montreal Neurological Institute (MNI), where his laboratory is part of the MNI’s Neurodegenerative Disease Research Group.
- University: McGill University
- School: Faculty of Medicine and Health Sciences
- Department: Department of Neurology and Neurosurgery
- Lab Affiliation: Brain Tumour Research Centre, Montreal Neurological Institute
Research Focus: Dr. McPherson’s lab investigates molecular mechanisms regulating endosomal membrane trafficking and its role in neurological disorders. Key areas include:
- Clathrin-coated pit/vesicle dynamics in neurons
- Links between trafficking defects and neurodevelopmental/neurodegenerative diseases (e.g., Parkinson’s, ALS, ARSACS, glioblastoma)
- Antibody validation via YCharOS initiative with industry partners
- Structural and functional characterization of trafficking proteins
Recent Trends: Publications emphasize antibody validation protocols (2024-2025), α-synuclein pathology in Parkinson’s, and DENND5A/RAB35 mutations in epileptic encephalopathy. Collaborative work spans lysosomal positioning, autophagy regulation, and C9orf72/SMCR8 complexes in inflammation.
Labs & Teams: The lab operates at the Montreal Neurological Institute in the Brain Tumour Research Centre, collaborating with 14 antibody manufacturers and knockout cell line providers through YCharOS. The team uses biochemical, molecular, structural, and cellular approaches to study endo/lysosomal pathways.
