معرفی
Paul Langlais, PhD, is an Associate Professor of Medicine in the Division of Endocrinology, Diabetes and Metabolism at the University of Arizona College of Medicine. He also serves as Director of the Proteomics Laboratory within the UA Center for Disparities in Diabetes, Obesity and Metabolism.
Education
- PhD – details not specified in the provided text.
Research Focus
Dr. Langlais’ laboratory investigates the molecular mechanisms underlying insulin signal transduction and the pathogenesis of insulin resistance and type 2 diabetes. Using cutting-edge mass-spectrometry-based proteomics, his group performs large-scale quantitative profiling to identify and characterise proteins that participate in insulin action. A major discovery from his work is the insulin-responsive protein CLASP2 (CLIP-associating protein 2), whose phosphorylation appears to regulate glucose uptake. Current efforts continue to dissect CLASP2’s role and to uncover additional novel components of the insulin signalling network.
Publication Landscape
Langlais’ recent publications (2019-2025) reveal an expansive research portfolio that integrates proteomics with metabolism, cardiovascular biology, neuroscience, cancer and reproductive toxicology. Recurring themes include mitochondrial energetics, microtubule and cytoskeletal regulation, endothelial and epithelial signalling, and the impact of environmental or metabolic stressors on protein networks. These studies leverage advanced multi-omics and phosphoproteomic approaches to map dynamic signalling events across diverse physiological and pathological contexts.
Laboratory & Teams
He directs the Proteomics Laboratory at the UA Center for Disparities in Diabetes, Obesity and Metabolism, providing core mass-spectrometry services while leading independent research projects. The laboratory supports collaborative investigations that extend from basic mechanistic studies to translational applications in diabetes, obesity and associated metabolic disorders.
Awards & Funding
No specific scientific awards or named grants are listed in the supplied text.
Student Mentoring
No individual student names are provided in the text.
