Patrick Aloy Calaf

Dr. Patrick Aloy Calaf is an ICREA Research Professor and Principal Investigator at the Institute for Research in Biomedicine (IRB Barcelona), leading the Structural Systems Biology lab. His academic journey includes a BSc in Biochemistry and an MSc in Biotechnology from the Autonomous University of Barcelona (UAB), followed by a postdoctoral and staff scientist role at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany.

His research merges structural bioinformatics, network biology, and systems pharmacology to analyze macromolecular assemblies using 3D structures. He has pioneered Structural Systems Pharmacology, integrating chemical and structural data for drug development, and developed tools like 3did, IntSide, and NetAligner to model protein interactions and networks.

• Key research areas:
  • 3D interactomes
  • Peptide-mediated interactions
  • Network medicine

His 150+ publications in journals like Nature, Cell, and PLoS reflect broad impact, with over 17,500 citations. His work spans from yeast interactome modeling to human disease networks, emphasizing structural insights in biological complexity.

The Structural Systems Biology lab under his leadership focuses on bridging computational models with experimental validation, advancing structural predictions for protein complexes and pathways.