معرفی
Patrick A. Frantom is a Professor in the Department of Chemistry and Biochemistry at The University of Alabama. His research integrates biochemical, bioinformatic, and biophysical techniques to study enzyme structure, function, and evolution. He leads projects funded by the NIH (R01-GM112919) and NSF CAREER Award, focusing on Fe-S cluster biogenesis and glycosyltransferase mechanisms.
- Education: PhD from Texas A&M University (2005), Postdoctoral Fellow at Albert Einstein College of Medicine (2005-2009)
Research highlights include:
- Investigating conformational dynamics and allosteric regulation in the Suf Fe-S cluster biogenesis pathway, critical for bacterial survival under oxidative stress.
- Exploring functional diversity in glycosyltransferase enzymes through structural and mechanistic studies using HDX-MS and bioinformatics.
- Collaborative work with experts like Dr. Jack Dunkle (UA) and Dr. Wayne Outten (University of South Carolina).
His lab employs advanced instrumentation including a Waters Xevo QToF mass spectrometer with HDX Manager UPLC system.
Scientific Awards:
- NSF CAREER Award MCB-1254077
The Frantom Lab actively engages in graduate training and is part of the broader University of Alabama research ecosystem.
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