Patricia R. Bachiller

Patricia R. Bachiller is a physician-scientist affiliated with Harvard Medical School and Boston Children's Hospital, where she conducts research at the intersection of pediatric critical care, neonatal lung development, and molecular pulmonary biology. Her work primarily focuses on bronchopulmonary dysplasia and the disruption of alveolar and microvascular development in premature infants.

• Harvard Medical School, M.D., 2001
• Brigham and Women's Hospital, Internal Medicine Internship, 2002
• Massachusetts General Hospital, Residency in Anesthesia and Critical Care, 2005
• Children's Hospital of Philadelphia, Pediatric Anesthesia and Critical Care Fellowship, 2006
• Massachusetts General Hospital, Research Fellowship, 2012

Dr. Bachiller’s research interests center on neonatal lung injury, particularly the molecular mechanisms underlying impaired alveolarization and vascular development. She investigates the role of nitric oxide signaling, soluble guanylate cyclase, and transforming growth factor-beta in lung repair and development. Her work combines basic science with clinical relevance, aiming to improve outcomes in preterm infants with bronchopulmonary dysplasia. She also explores broader healthcare issues, including physician well-being and systemic factors in medical culture.

Her publication record spans from undergraduate and graduate research in NMR spectroscopy and actin regulatory proteins to translational work in pediatric ventilation and lung morphogenesis. Recent articles highlight her dual focus on molecular lung biology and healthcare systems. Over time, her work has evolved from biophysical studies to clinically oriented research in neonatal pulmonology and critical care.

Scientific contributions include:

• Investigating ventilator accuracy in pediatric anesthesia
• Elucidating TGF-beta and NO pathway interactions in lung injury
• Developing models of alveolarization and vascular development
• Advocating for cultural change to support clinician well-being

Dr. Bachiller has contributed to textbook chapters in critical care and has mentored trainees through her roles in academic anesthesiology and research. While specific grants and advisees are not listed, her sustained research output and leadership in niche areas suggest active grant funding and academic mentorship. She has been involved in research cores and interdisciplinary teams at Massachusetts General Hospital and Boston Children's Hospital, contributing to both basic and clinical research infrastructure.