معرفی
Patricia Muller is an Associate Professor in the Department of Biosciences at Durham University. She earned her Ph.D. from UMC Utrecht in the Netherlands, followed by a Rubicon fellowship-supported postdoc at the CRUK Beatson Institute. Her research investigates mutant p53 gain-of-function mechanisms in cancer progression, focusing on invasion, metastasis, chemoresistance, and metal toxicity effects. Key research areas include:
- Mutant p53-driven invasion and metastasis via RCP and integrin trafficking
- Cell-in-cell structures and their role in tumorigenesis
- Metal-induced p53 unfolding and functional alteration
- Therapeutic targeting of mutant p53 cancers
Recent publications explore SH3BGRL-mediated cell engulfment, taurine metabolism in ovarian cancer, RCP-dependent chemoresistance mechanisms, and ultraviolet-induced melanoma suppression. Her work incorporates biochemical, molecular, and imaging approaches including iRFP tumor imaging.
Awards include the Biochemical Society Early Career Award (2016). She maintains industry collaborations with Pleco Therapeutics to develop novel cancer therapies.
She currently supervises six research students working on p53 signaling, metal toxicity, and cancer cell dynamics. Laboratory techniques include CRISPR, proteomics, live-cell imaging, and preclinical cancer models.
